glp 1 function Glucagon-like peptide in health and disease Comprehensive mechanistic diagram showing GLP-1

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Dans ce mcanisme, il y a dans un premier temps fixation du substrat A sur l'enzyme pour former le complexe EA avec libration du premier produit

Hsueh Y-J, Chen Y-N, Tsao Y-T, Cheng C-M, Wu W-C, Chen H-C (2022) The pathomechanism, antioxidant biomarkers, and treatment of oxidative stress-related eye diseases

Therefore, one possible mechanism for the GI intolerance associated with metformin may relate to altered transport of serotonin or to a direct serotonergic-like effect of metformin